As you can make adgustables town size, it would be great to make bigger towns, as with many AI and lot of factories and farms the map is quickly full.
Factories and R&D with many floors could help too. Or just factory upgrade (same size but better robots (MFT), it's better than to build many factories to process the same things

To fight pollution, maybe setup specific towns, somes with only industries and mines, and some others with only residentials and commercials

Thanks
CHOUM