
For example a lot of time I don't bother go into the user-defined layout simply because the real hand movement isn't that much of a difference, when I memorized all layouts I used by heart.
The "faster way" using defined layout is : [moving your hand to F7, which usually far from normal typing area, press F7, move you mouse to pre-defined, click, move-back to selection menu, click, than use hotkey and then scroll, and double click again, move you mouse again to use, click, move to confirm screen and click OK]
The "original way" is : [double click in empty unit, and double click a unit function very close by, than the next, total 9 times, and establish links around the same area double clicks about 10 times]. A lot double clicks, but few wrist movement toward different target.
Obviously the use of hotkeys combined with mouse selection greatly increase input bandwidth, since you can use different hands, and many fingers. However the mixed of both isn't that of an improvement in saving actual game play time. UI can be streamlined to use keyboard mostly like F7, U(User pre-defined), select first product's first letter, second letter, etc, enter(choose), E(use), enter(comfirm). A lot lot faster and save actual game play time.
Although that being said, I suppose with increasing contents still being added over time, perhaps the UI streamline isn't that higher up in priority for design team. Or it could change a lot in the future and cause hotkeys conflict.